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   Prof Henry Nettey

  Associate Professor

  hnettey@ug.edu.gh 

  

   Academic Qualifications

  • Doctor of Pharmacy/Doctor of Philosophy (PharmD/PhD) Pharmaceutics, Mercer University, Atlanta, U.S.A
  • Bachelor of Science (B. Sc.) Microbiology, University of Toronto, Toronto, Canada.

Prof. Nettey specializes in drug formulations and his research focuses on micro and nanoparticulate drug formulations and drug targeting. Prof. Nettey has authored and co-authored numerous articles which have been published in renowned peer-reviewed journals. He has won a number of research grants and presented his work at high profile meetings such as American Society of Pharmaceutical Scientists (AAPS) and the Tropical Medicine Conference in the U.S.A. Prof. Nettey received his Bachelor of Science degree in Microbiology from the University of Toronto in 1994, and was the first person to obtain a dual PharmD/PhD degree in Pharmacy and Pharmaceutical Sciences at Mercer University, Atlanta, Georgia in 2005.

Research Interests

  • Micro and nano-particulate drug formulations
  • Targeted Drug Delivery
  • Novel Treatment Options for Neglected Tropical Diseases
  • Drug Quality Control

Current Research

  • Quality assessment of various classes of drugs using established and/or innovative methods
  • Preparation, characterization and evaluation of micro/nano particulate formulations of anti-infectives.
  • In vitro and in vivo distribution and activity of micro/nano particulate formulations
  • Screening of anti-infectives for activity against microbes and drug repurposing

Projects

  • Antimicrobial drug screening against Mycobacterium smegmatis: The objectives of this study are to determine if antimicrobials, used for other indications, will be effective in inhibiting the growth of Mycobacterium smegmatis and hopefully extrapolated to the treatment of Mycobacterium tuberculosis infections.
  • Antimicrobial drug screening against Leishmania donovani: In this study, we are investigating the effect of various individual antimicrobials  as well as combinations of them against the growth of Leishmania donovani parasites.
  • Formulation and Characterization of anti-leishmania drug nano/micro particles: This study focuses on the preparation of nano and microparticulate formulations of antimicrobials found to be effective against Leishmania donovani. The formulations are analyzed for drug content, particle size range, encapsulation efficiency and in vitro release kinetics.
  • In vitro effect of nano-particulate antimicrobial formulations on intracellular Leishmania donovani: The objective of this study was to compare the in vitro efficacy of selected nanoparticulate antimicrobial drugs with the standard anti-Leishmania drugs. Human macrophage cells are allowed to engulf L. donovani parasites after which the same macrophages are treated with nanoparticulate drug particle or solution formulations.
  • In vivo effect of nano-particulate antimicrobial formulations on intracellular Leishmania donovani: In this study rats are infected with L. donovani cells and then treated with either standard anti-leishmania drug formulations or nano-partculate drug formulations.
  • Quality of anti-malarial drug formulations found in Pharmacies in Accra: The objective of this study was to assess the quality of artemether-Lumefantrine drug formulations on the Ghanaian market using a validated colorimetric method developed by the U.S Centers for Disease Control and Prevention.
  • Quality of amoxicillin-clavulanic acid formulations obtained in the Central Region of Ghana: This study investigated the quality of various brands of amoxicillin-clavulanic acid formulations purchased in Pharmacies in the Central Region of Ghana. The drug content and dissolution profile were determined using HPLC and USP dissolution equipments

Publications

  • Grace Lovia Allotey-Babington, Henry Nettey, Nana Kwame Ofori Gyamera, Nana Aboadwe Goode, Afia Antwi Mensah, Isaac Julius Asiedu-Gyekye, Doris Kumadoh, Isaac Joe Erskine. Development and evaluation of an oral quinine sulphate sustained release formulation for the management of visceral leishmaniasis, Int. J. Res. Pharm. Sci., 2024. 15 (4), 48-55.
  • Grace Lovia Allotey-Babington, Irene Akwo-Kretchy, Isaac Julius Asiedu-Gyekye, Maame Kyiafi Oppong-Beniako, Obed Kufoalor, Gilnel Adjei Adjetey, Michael Agyapong Mintah, Henry Nettey. Availability and types of pressure ulcer medications at community pharmacies in the Accra metropolis of Ghana. Innov. Pharm. 2024. 15 (3) 10. PMCID: PMC11524219  PMID: 39483512
  • Grace Lovia Allotey-Babington, Irene Akwo-Kretchy, Esther Atiapa Asiedu, Maxine Kelly Amuakwa, Obedia Akwele Seaneke, Daniel Ankrah, Abredu Kwadwo Somuah, Agatha Dei Owusu-Nyamekye, Sarah Owusu-Ansah, Patrick Kwame Effah, Johnson Debrah, Edna Acheamponmaa Nai, Emmanuel Owusu, William Lamptey, Isaac Julius Asiedu-Gyekye, Henry Nettey. Prevalence, scope and quality of extemporaneous medications in selected healthcare facilities and implications for pharmacy practice. Innov. Pharm. 2024. 15 (1) 10.
  • Cletus Anes Ukwubile, Henry Nettey, Troy Salvia Malgwi, Nnamdi David Menkiti. Ruellia simples C.  Wright (Acanthaceae): Antinociceptive, anti-inflammatory, and antidiabetic activities of a novel fatty acid isolated from its leaf extract, International Journal of Plant Based Pharmaceuticals (2023), Int. J. Plant Bas. Pharm. (2023) 3 (1), 32-40
  • Henry Nettey, Isaac Joe Erskine , Afia Antwi Mensah, Nana Kwame Ofori Gyamera, Charles Kwadwo Obuobi, Doris Kumadoh , Grace Lovia Allotey-Babington. Oral Amodiaquine Microparticles Repurposed for the Treatment of Visceral Leishmaniasis, Scientific African (2022), doi: https://doi.org/10.1016/j.sciaf.2022 .e01285
  • Grace Lovia Allotey-Babington; Obedia Akwele Seaneke; Abigail Annan Williams ; Esther Atiapa Asiedu; Maxine Kelly Amuakwa; Henry Nettey. Hydroxyurea granules for the management of sickle cell disease in children. Scientific African 16 (2022), e01271. https://doi.org/10.1016/j.sciaf.2022.e01271
  • Benedicta Obenewaa Dankyi, MPhil, Seth Kwabena Amponsah, PhD, Grace Lovia Allotey-Babington, PhD, Ismaila Adams, BPharm, Nana Aboadwe Goode, BPharm, Henry Nettey, PharmD/PhD. Chitosan-coated hydroxypropylmetthylcellulose microparticles of levodopa (and carbidopa): In vitro and rat-model kinetic characteristics. Current Therapeutic Research 93(2020) 100612.
  • Grace Lovia Allotey-Babington, Henry Nettey, Martin J D’Souza. Doxetaxel-Dasatinib combination: A strategy to overcme unfavouarble treatment outcomes due to dose reduction. Journal of Drug Discovery Science and Technology (2020). https://doi.org/10.1016/j.jddst.2020.102085
  • Grace Lovia Allotey-Babington, Seth Kwabena Amponsah, Thomas Nettey, Clement Sasu and Henry Nettey. Quinine sulphate microparticles as treatment for Leishmaniasis.Journal of Tropical Medicine (2020). https://doi.org/10.1155/2020/5278518
  • C.A Okwubile, E.O. Ikpefan, T.S. Malgwi, A.B. Bababe, J.A. Odugu, A.N. Angyu, O. Otalu, M.S. Bingari, H. Nettey. Cytotoxic effects of new bioactive compounds isolated from a Nigerian anticancer plant Melastomastrum capitatum Fern. Leaf extract. Scientific African 8 (2020) e00421. www.elsevier.com/locate/sciaf
  • Emelia Oppong Bekoe, Christian Agyare, Yaw Duah Boakye, Benedict Mbeah Baiden, Alex Asase, Joseph Sarkodie, Henry Nettey, Francis Adu, Priscilla Boatema Otu, Ethnomedicinal survey and mutagenic studies of plants used in Accra metropolis, Ghana. Journal of Ethnopharmacology 248 (2020) 112309. www.elsevier.com/locate/jethpharm
  • Kwabena Frimpong-Manso Opuni, Henry Nettey, Marvin Adjei Larbi, Salome Naa Amerley Amartey, Gifty Nti, Abraham Dzidonu, Patrick Owusu-Danso, Nicholas Amoah Owusu, Alexander Kwadwo Nyarko (2019). Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method. Malaria journal (2019) 18:403. https://doi.org/10.1186/s12936-019-3045-y
  • Cletus A. Ukwubile, Abubakar Ahmed, Umar A. Katsayal, Jamilu Ya’u, Henry Nettey (2019) In vitro anticancer activity of Melastomastrum capitatum fern loaded chitosan nanoparticles on selected cancer cells. Drug Discovery, 13, 46-54.
  • Grace Lovia Allotey-Babington, Henry Nettey, Sucheta D’Sa, Kimberly Braz Gomes, Martin J. D’Souza (2018) Cancer Chemotherapy: Effect of poloxamer modified nanoparticles on cellular function. Journal of Drug Delivery Science and Technology 47, (2018) 181-192.
  • Henry Nettey, Grace Lovia Allotey-Babington, Isaac Somuah, N ’guessan Benoit Banga, Barima Afrane, Seth Kwabena Amponsah, Henrietta Annor, Henry Darko, Kwame Hanson, Anoa Aidoo, Marisa Nyarkoa Broni, Clement Sasu and Alexander Nyarko (2017) Assessment of formulated amodiaquine microparticles in Leishmania donovani infected rats. Journal of Microencapsulation, Published online January 23, 2016. http://dx.doi.org/10.1080/02652048.2017.1280094
  • Philip Debrah, Henry Nettey,Katja Kjeldgaard Miltersen, Patrick Ayeh-Kumi, Birgitte Brock, Joseph Sarkodie, Irene Akwo-Kretchy, Patrick Owusu-Danso, Samuel Adjei, Eskild Petersen,and Tore Forsingdal Hardlei (2016) Artemether–Lumefantrine Concentrations in Tablets and Powders from Ghana Measured by a New High-Performance Liquid Chromatography Method. Am J Trop Med Hyg 15-0868; Published online May 2, 2016,
  • Osei-Safo D, Egbo HA, Nettey H, Konadu DY and Addae-Mensah I: Evaluation of the Quality of Some Antibiotics Distributed In Accra and Lagos. Int J Pharm Sci Res 2016; 7(5): 1991-2000.doi: 10.13040/IJPSR.0975-8232.7(5).1991-2000
  • Ukwubile Cletus Anes, Henry Nettey, Joshua Vopah Jen (2016).  Antimicrobial Activity and Characterization of Annona Muricata Linn (Annonaceae) Leaf- Loaded Chitosan Nanoparticle against Cancer Associated Microbes. International Journal of Research Studies in Microbiology and Biotechnology (IJRSMB) Volume 2, Issue 1, 2016, PP 15-21 ISSN 2454-9428 (Online) www.arcjournals.org
  • Henry Nettey, Grace Lovia Allotey-Babington, Benoit Banga Nguessan, Barima Afrane, Mustafa Tagoe, Anokye Ababio, Patience Botchway, Yvonne Darko, Clement Sasu, Alexander Nyarko (2016) Screening of Anti-Infectives Against Leishmania donovani. Advances in Microbiology 6, 13-22.
  • Michael D. Green, Dana M. Hostetler, Henry Nettey, Isabel Swamidoss, Nicola Ranieri, Paul N. Newton. Integration of Novel Low-cost Colorimetric, Laser Photometric and Visual Fluorescent Techniques for Rapid Identification of Falsified Medicines in Resource-poor Areas: Application to Artemether-lumefantrine. American Journal of Tropical Medicine and Hygiene. Published online April 20, 2015.  http://ajtmh.org/cgi/doi/10.4269/ajmh 14-0832
  • Evelyn Addo, Rodney C. Siwale, Aladin Siddig, Alphia Jones, Ruhi V. Ubale, Janet Akande, Henry Nettey, Neil J. Patel, Martin J. D’Souza, Richard T. Addo. Formulation and Characterization of Atropine Sulfate in Albumin-Chitosan Microparticles for In Vivo Ocular Drug Delivery. Journal of Pharmaceutical Sciences. Published on Line January 2015. Wileyonlinelibrary.com. DOI 10.1002/jps.24380
  • Grace Lovia Allotey-babington, Henry Nettey, Philip Debrah, Ofosua Adi-Dako, Clement Sasu, Anastasia Antwi, Yvonne Darko, Newriza Nartey, Jida Asare, Screening of Several Anti-Infectives for in vitro activity against Mycobacterium smegmatis Advances in Microbiology, 2014, 4, 1197-1203.
  • Henry Nettey, Grace Lovia Allotey-Babington, Philip Debrah, Ofosuah Adi-Dako, Manal Shaick, Isaac Kintoh, Francis Arnansi, Makafui Nyaglordzro and Marvin Holison.  The Quality and In Vitro Efficacy of Amoxicillin/Clavulanic Acid Formulations in the Central Region of Ghana. Pharmacology and Pharmacy 5, 49-60.  Published Online January 2014 (http://www.scirp.org/journal/pp)  http://dx.doi.org/10.4236/pp.2014.51009
  • Ebenezer Adu-Nyarko and Henry Nettey. Quality Assessment of Artemether/Lumefantrine Tablets Sampled from Pharmacies in Accra, Using the MVHimagePCv8.exe Color Software. Pharmacology & Pharmacy, 2013, 4, 567-572 Published Online November 2013 (http://www.scirp.org/journal/pp) http://dx.doi.org/10.4236/pp.2013.48081
  • Henry Nettey, Grace Lovia Allotey-Babington, Martin J. D’Souza.  The Evaluation of Vancomycin Microspheres on Intracellular Staphylococcus aureus and the Effect of Bacteria on Eukaryotic Cell Wall Permeability. Pharmacology & Pharmacy, 2013, 4, 385-391. doi:10.4236/pp.2013.44055 Published Online July 2013 (http://www.scirp.org/journal/pp)
  • Jimee Hwang., Bereket Hailegiorgis Alemayehu., Richard Reithinger, Samuel Girma Tekleyohannes, Takele Teshi, Sintayehu Gebresillasie Birhanu, Leykun Demeke, David Hoos, Zenebe Melaku, Moges Kassa, Daddi Jima, Joseph L. Malone, Henry Nettey, Michael Green, Amanda Poe, Sheila Akiny, Venkatachalam Udhayakumar, S. Patrick Kachur, Scott Filler.  In Vivo Efficacy of Artemether-Lumefantrine and Chloroquine against Plasmodium vivax: A Randomized Open Label Trial in Central Ethiopia. PLoS ONE 2013 8(5): e63433. doi:10.1371/journal.pone.0063433
  • Paul N Newton, Michael D Green, Dallas C Mildenhal, Aline Plancon, Henry Nettey, Leonard Nyadong, Dana M Hosteller, Isabel Swamidoss, Glenn A Harris, Kristen Powell, Anss E Timmermans, Abdinassir A Amin, Stephen K Opuni, Serge Barbereau, Claude Faurant, Ray CW Soong, Kevin Faure, Jonathan Thevanayagam, Peter Fernandes, Harpakash Kaur, Brian Angus, Kasia Stephiewska, Philippe J Guerin, Facundo M Fernandez. Poor quality vital anti-malarials in Africa- an urgent neglected public health priority. Malaria Journal 2011, 10:352.
  • Alphia K. Jones, Naveen K. Bejugam, Henry Nettey, Richard Addo, and Martin D’Souza. Spray-dried doxorubicin-albumin micropariculate systems for treatment of multidrug resistant melanomas. J. Drug Targeting. 19 (6) 2011, 427-433.
  • Jimee Hwang, Bereket H Alemayehu, David Hoos, Zenebe Melaku, Samuel G Tekleyohannes, Takele Teshi, Sintayehu G Birhanu, Leykun Demeke, Kedir Gobena, Moges Kassa, Daddi Jima7, Richard Reithinger, Henry Nettey, Michael Green, Joseph L Malone, S Patrick Kachur, Scott Filler.  In vivo Efficacy of artemether-lumefantrine against uncomplicated plasmodium falciparum malaria in central Ethiopia. Malaria Journal, 2011, 10:209.
  • Pawan K. Angra, Aladin Siddig, Henry Nettey, Nishil Desai, Carl Oettinger and Martin J. D’Souza.                Pharmacokinetic and biodistribution studies of Amphotericin B microspheres. J. Microencapsulation, 2009, 1-8.
  • Sei Won Lee, Minhee Lee, Dae Dong Lee, Changsoo Kim, Yeon-Joo Kim, Jung-Yeon Kim, Michael D. Green, Terry A. Klein, Heung Chal Kim, Henry Nettey, Dong Hoon .Ko,Hyungsuk Kim, and Inho Park.      Biological Resistance of Hydroxychloroquine for Plasmodium vivax Malaria in the Republic of Korea. Am. J. trop. Med. Hyg., 81(4) 2009, 600-604.
  • Green MD, Nettey H, Wirtz RA. Determination of Oseltamivir quality by colorimetric and liquid chromatographic methods. Emerg Infect Dis. 2008, 14(4): 552-556 (2008)
  • Nettey H., Haswani D., Oettinger C., and D’Souza M.J. In Vitro antimicrobial effect of encapsulated vancomycin on Internalized Staphylococcus aureus within endothelial cells. Drug Dev Ind. Pharm. 2007, 33 (2): 133-9
  • Haswani D.K, Nettey H.,D’Souza M.J., and Oettinger C.W In vitro evaluation and targeting of E. Coli internalized by Endothelial cells using albumin microspheres loaded with gentamicin. Drug Dev Ind. Pharm. 2007, 33 (2): 181-190
  • Green M.D., Van Eijk A.M., Ayisi J.G., Parise M.E., Kager A.P., Nahlen B.L., Steketee R. and Nettey H. Pharmacokinetics of sulfadoxine-pyrimethamine in HIV –Infected and Uninfected Pregnant Women in Western Kenya. J. of Infectious Diseases. 2007, 196: 1403-8
  • Green M.D., Nettey H., Rojas O.V., Pamanivong C., Khousaknalath L., Ortiz M.G., Newton P.N., Fernandez F.M., Vongsack L., and Manolin O. Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality. J. Pharm. and Biom. Anal. 2007, 43: 105 – 110
  • Nettey H., Haswani D., Oettinger C., and D’Souza M.J.   Formulation and testing of vancomycin loaded albumin Microspheres prepared by spray-drying. J. Microencapsulation. 2006, 23(6): 632-642
  • Haswani K.D, Nettey H., Oettinger C., and D’Souza M.J. Formulation, characterization and pharmacokinetic Evaluation of gentamicin sulphate loaded albumin Microspheres. J. Microencapsulation. 2006, 23(8): 885-886
  • Green M.D., Mount D.L., and Nettey H. High-performance liquid chromatographic assay for the simultaneous determination of sulfadoxine and pyrimethamine from whole blood dried onto filter paper. J. Chrom. B. 2002, 767: 159-162